Long noncoding RNAs (lncRNAs) and the molecular hallmarks of aging | Zendy

Ioannis Grammatikakis | Zendy; Amaresh C. Panda | Zendy; Kotb Abdelmohsen | Zendy; Myriam Gorospe | Zendy

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Long noncoding RNAs (lncRNAs) and the molecular hallmarks of aging

Author(s) -

Ioannis Grammatikakis,

Amaresh C. Panda,

Kotb Abdelmohsen,

Myriam Gorospe

Publication year - 2014

Publication title -

aging

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.473

H-Index - 90

ISSN - 1945-4589

DOI - 10.18632/aging.100710

Subject(s) - proteostasis , epigenetics , biology , telomere , genome instability , phenotype , senescence , disease , long non coding rna , cellular senescence , microrna , genetics , dna damage , rna , gene , medicine , dna , pathology

During aging, progressive deleterious changes increase the risk of disease and death. Prominent molecular hallmarks of aging are genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, cellular senescence, stem cell exhaustion, and altered intercellular communication. Long noncoding RNAs (lncRNAs) play important roles in a wide range of biological processes, including age-related diseases like cancer, cardiovascular pathologies, and neurodegenerative disorders. Evidence is emerging that lncRNAs influence the molecular processes that underlie age-associated phenotypes. Here, we review our current understanding of lncRNAs that control the development of aging traits.

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