Cardiac BNP gene delivery prolongs survival in aged spontaneously hypertensive rats with overt hypertensive heart disease | Zendy

Jason M. Tonne | Zendy; Sara J. Holditch | Zendy; Elise A. Oehler | Zendy; Claire A. Schreiber | Zendy; Yasuhiro Ikeda | Zendy; Alessandro Cataliotti | Zendy

Open Access

Cardiac BNP gene delivery prolongs survival in aged spontaneously hypertensive rats with overt hypertensive heart disease

Author(s) -

Jason M. Tonne,

Sara J. Holditch,

Elise A. Oehler,

Claire A. Schreiber,

Yasuhiro Ikeda,

Alessandro Cataliotti

Publication year - 2014

Publication title -

aging

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.473

H-Index - 90

ISSN - 1945-4589

DOI - 10.18632/aging.100655

Subject(s) - medicine , hypertensive heart disease , transduction (biophysics) , cardiac function curve , gene delivery , genetic enhancement , cardiology , heart failure , heart disease , disease , endocrinology , gene , biology , biochemistry

Hypertension is a highly prevalent disease associated with cardiovascular morbidity and mortality. Recent studies suggest that patients with hypertension also have a deficiency of certain cardiac peptides. Previously we demonstrated that a single intravenous injection of the myocardium-tropic adeno-associated virus (AAV) 9-based vector encoding for proBNP prevented the development of hypertensive heart disease (HHD) in spontaneously hypertensive rats (SHRs). The current study was designed to determine the duration of cardiac transduction after a single AAV9 injection and to determine whether cardiac BNP overexpression can delay the progression of previously established HHD, and improve survival in aged SHRs with overt HHD.

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