Serum profiling of healthy aging identifies phospho- and sphingolipid species as markers of human longevity | Zendy

Ivan Montoliu | Zendy; Max Scherer | Zendy; Fiona Beguelin | Zendy; Laeticia DaSilva | Zendy; Daniela Mari | Zendy; Stefano Salvioli | Zendy; FrançoisPierre Martin | Zendy; Miriam Capri | Zendy; Laura Bucci | Zendy; Rita Ostan | Zendy; Paolo Garagnani | Zendy; Daniela Monti | Zendy; Elena Biagi | Zendy; Patrizia Brigidi | Zendy; Martin Kussmann | Zendy; Serge Rezzi | Zendy; Claudio Franceschi | Zendy; Sebastiano Collino | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Serum profiling of healthy aging identifies phospho- and sphingolipid species as markers of human longevity

Author(s) -

Ivan Montoliu,

Max Scherer,

Fiona Beguelin,

Laeticia DaSilva,

Daniela Mari,

Stefano Salvioli,

FrançoisPierre Martin,

Miriam Capri,

Laura Bucci,

Rita Ostan,

Paolo Garagnani,

Daniela Monti,

Elena Biagi,

Patrizia Brigidi,

Martin Kussmann,

Serge Rezzi,

Claudio Franceschi,

Sebastiano Collino

Publication year - 2014

Publication title -

aging

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.473

H-Index - 90

ISSN - 1945-4589

DOI - 10.18632/aging.100630

Subject(s) - longevity , sphingolipid , gerontology , profiling (computer programming) , biology , medicine , genetics , computer science , operating system

As centenarians well represent the model of healthy aging, there are many important implications in revealing the underlying molecular mechanisms behind such successful aging. By combining NMR metabonomics and shot-gun lipidomics in serum we analyzed metabolome and lipidome composition of a group of centenarians with respect to elderly individuals. Specifically, NMR metabonomics profiling of serum revealed that centenarians are characterized by a metabolic phenotype distinct from that of elderly subjects, in particular regarding amino acids and lipid species. Shot- gun lipidomics approach displays unique changes in lipids biosynthesis in centenarians, with 41 differently abundant lipid species with respect to elderly subjects. These findings reveal phospho/sphingolipids as putative markers and biological modulators of healthy aging, in humans. Considering the particular actions of these metabolites, these data are suggestive of a better counteractive antioxidant capacity and a well-developed membrane lipid remodelling process in the healthy aging phenotype.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research