QTL mapping of leukocyte telomere length in American Indians: The Strong Heart Family Study | Zendy

Yun Zhu | Zendy; V. Saroja Voruganti | Zendy; Jue Lin | Zendy; Tet Matsuguchi | Zendy; Elizabeth H. Blackburn | Zendy; Lyle G. Best | Zendy; Elisa T. Lee | Zendy; Jean W. MacCluer | Zendy; Shelley A. Cole | Zendy; Jinying Zhao | Zendy

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QTL mapping of leukocyte telomere length in American Indians: The Strong Heart Family Study

Author(s) -

Yun Zhu,

V. Saroja Voruganti,

Jue Lin,

Tet Matsuguchi,

Elizabeth H. Blackburn,

Lyle G. Best,

Elisa T. Lee,

Jean W. MacCluer,

Shelley A. Cole,

Jinying Zhao

Publication year - 2013

Publication title -

aging

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.473

H-Index - 90

ISSN - 1945-4589

DOI - 10.18632/aging.100600

Subject(s) - quantitative trait locus , telomere , heritability , genetics , biology , dementia , odds ratio , disease , population , diabetes mellitus , chromosome , genome wide association study , medicine , demography , gerontology , single nucleotide polymorphism , genotype , environmental health , gene , endocrinology , sociology

Telomeres play a central role in cellular senescence and are associated with a variety of age-related disorders such as dementia, Alzheimer's disease and atherosclerosis. Telomere length varies greatly among individuals of the same age, and is heritable. Here we performed a genome-wide linkage scan to identify quantitative trait loci (QTL) influencing leukocyte telomere length (LTL) measured by quantitative PCR in 3,665 American Indians (aged 14-93 years) from 94 large, multi-generational families. All participants were recruited by the Strong Heart Family Study (SHFS), a prospective study to identify genetic factors for cardiovascular disease and its risk factors in American Indians residing in Oklahoma, Arizona and Dakota. LTL heritability was estimated to be between 51% and 62%, suggesting a strong genetic predisposition to interindividual variation of LTL in this population. Significant QTLs were localized to chromosome 13 (Logarithm of odds score (LOD)=3.9) at 13q12.11, to 18q22.2 (LOD=3.2) and to 3p14.1 (LOD=3.0) for Oklahoma. This is the first study to identify susceptibility loci influencing leukocyte telomere variation in American Indians, a minority group suffering from a disproportionately high rate of type 2 diabetes and other age-related disorders.

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