Rapamycin extends life- and health span because it slows aging
Author(s) -
Mikhail V. Blagosklonny
Publication year - 2013
Publication title -
aging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.473
H-Index - 90
ISSN - 1945-4589
DOI - 10.18632/aging.100591
Subject(s) - life span , longevity , pi3k/akt/mtor pathway , successful aging , psychology , biology , developmental psychology , gerontology , medicine , evolutionary biology , microbiology and biotechnology , signal transduction
Making headlines, a thought-provocative paper by Neff, Ehninger and coworkers claims that rapamycin extends life span but has limited effects on aging. How is that possibly possible? And what is aging if not an increase of the probability of death with age. I discuss that the JCI paper actually shows that rapamycin slows aging and also extends lifespan regardless of its direct anti-cancer activities. Aging is, in part, MTOR-driven: a purposeless continuation of developmental growth. Rapamycin affects the same processes in young and old animals: young animals' traits and phenotypes, which continuations become hyperfunctional, harmful and lethal later in life.
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