Chronic oxidative stress upregulates Drusen-related protein expression in adult human RPE stem cell-derived RPE cells: A novel culture model for dry AMD | Zendy

David M. Rabin | Zendy; Richard L. Rabin | Zendy; Timothy A. Blenkinsop | Zendy; Sally Temple | Zendy; Jeffrey H. Stern | Zendy

Open Access

Chronic oxidative stress upregulates Drusen-related protein expression in adult human RPE stem cell-derived RPE cells: A novel culture model for dry AMD

Author(s) -

David M. Rabin,

Richard L. Rabin,

Timothy A. Blenkinsop,

Sally Temple,

Jeffrey H. Stern

Publication year - 2012

Publication title -

aging

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.473

H-Index - 90

ISSN - 1945-4589

DOI - 10.18632/aging.100516

Subject(s) - drusen , downregulation and upregulation , oxidative stress , biology , macular degeneration , retinal pigment epithelium , retinal , microbiology and biotechnology , cell , andrology , immunology , endocrinology , medicine , gene , biochemistry , ophthalmology

The goal of this study was to examine changes in the expression of transcripts and proteins associated with drusen in Age-related Macular Degeneration (AMD) after exposing human retinal pigment epithelium (hRPE) cells to chronic oxidative stress.

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