Low circulating IGF-I bioactivity is associated with human longevity: Findings in centenarians’ offspring | Zendy

Giovanni Vitale | Zendy; Michael P. Brugts | Zendy; Giulia Ogliari | Zendy; Davide Castaldi | Zendy; Letizia Maria Fatti | Zendy; Aimee J. Varewijck | Zendy; Steven W. J. Lamberts | Zendy; Daniela Monti | Zendy; Laura Bucci | Zendy; Elisa Cevenini | Zendy; Francesco Cavagnini | Zendy; Claudio Franceschi | Zendy; Leo J. Hofland | Zendy; Daniela Mari | Zendy; J. A. M. J. L. Janssen | Zendy

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Low circulating IGF-I bioactivity is associated with human longevity: Findings in centenarians’ offspring

Author(s) -

Giovanni Vitale,

Michael P. Brugts,

Giulia Ogliari,

Davide Castaldi,

Letizia Maria Fatti,

Aimee J. Varewijck,

Steven W. J. Lamberts,

Daniela Monti,

Laura Bucci,

Elisa Cevenini,

Francesco Cavagnini,

Claudio Franceschi,

Leo J. Hofland,

Daniela Mari,

J. A. M. J. L. Janssen

Publication year - 2012

Publication title -

aging

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.473

H-Index - 90

ISSN - 1945-4589

DOI - 10.18632/aging.100484

Subject(s) - longevity , offspring , centenarian , gerontology , humanities , biology , philosophy , medicine , genetics , pregnancy

Centenarians' offspring represent a suitable model to study age-dependent variables (e.g. IGF-I) potentially involved in the modulation of the lifespan. The aim of the present study was to investigate the role of the IGF-I in human longevity. We evaluated circulating IGF-I bioactivity measured by an innovative IGF-I Kinase Receptor Activation (KIRA) Assay, total IGF-I, IGFBP-3, total IGF-II, insulin, glucose, HOMA2-B% and HOMA2-S% in 192 centenarians' offspring and 80 offspring-controls of which both parents died relatively young. Both groups were well-matched for age, gender and BMI with the centenarians' offspring. IGF-I bioactivity (p〈0.01), total IGF-I (p〈0.01) and the IGF-I/IGFBP-3 molar ratio (p〈0.001) were significantly lower in centenarians' offspring compared to offspring matched-controls. Serum insulin, glucose, HOMA2-B% and HOMA2-S% values were similar between both groups. In centenarians' offspring IGF-I bioactivity was inversely associated to insulin sensitivity.

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