Caloric restriction: is mammalian life extension linked to p53? | Zendy

Paola Tucci | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Caloric restriction: is mammalian life extension linked to p53?

Author(s) -

Paola Tucci

Publication year - 2012

Publication title -

aging

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.473

H-Index - 90

ISSN - 1945-4589

DOI - 10.18632/aging.100481

Subject(s) - longevity , caloric theory , biology , limiting , apoptosis , neuroscience , microbiology and biotechnology , genetics , endocrinology , mechanical engineering , engineering

Caloric restriction, that is limiting food intake, is recognized in mammals as the best characterized and most reproducible strategy for extending lifespan, retarding physiological aging and delaying the onset of age-associated diseases. The aim of this mini review is to argue that p53 is the connection in the abilities of both the Sirt-1 pathway and the TOR pathway to impact on longevity of cells and organisms. This novel, lifespan regulating function of p53 may be evolutionarily more ancient than its relatively recent role in apoptosis and tumour suppression, and is likely to provide many new insights into lifespan modulation.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research