Age-related cognitive decline: Can neural stem cells help us? | Zendy

Benedetta Artegiani | Zendy; Federico Calegari | Zendy

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Age-related cognitive decline: Can neural stem cells help us?

Author(s) -

Benedetta Artegiani,

Federico Calegari

Publication year - 2012

Publication title -

aging

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.473

H-Index - 90

ISSN - 1945-4589

DOI - 10.18632/aging.100446

Subject(s) - neurogenesis , neural stem cell , neuroscience , cognitive decline , cognition , stem cell , psychology , biology , medicine , microbiology and biotechnology , dementia , disease

Several studies suggest that an increase in adult neurogenesis has beneficial effects on emotional behavior and cognitive performance including learning and memory. The observation that aging has a negative effect on the proliferation of neural stem cells has prompted several laboratories to investigate new systems to artificially increase neurogenesis in senescent animals as a means to compensate for age-related cognitive decline. In this review we will discuss the systemic, cellular, and molecular changes induced by aging and affecting the neurogenic niche at the level of neural stem cell proliferation, their fate change, neuronal survival, and subsequent integration in the neuronal circuitry. Particular attention will be given to those manipulations that increase neurogenesis in the aged brain as a potential avenue towards therapy.

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