Molecular damage in cancer: an argument for mTOR-driven aging | Zendy

Mikhail V. Blagosklonny | Zendy

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Molecular damage in cancer: an argument for mTOR-driven aging

Author(s) -

Mikhail V. Blagosklonny

Publication year - 2011

Publication title -

aging

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.473

H-Index - 90

ISSN - 1945-4589

DOI - 10.18632/aging.100422

Subject(s) - cancer , disease , argument (complex analysis) , cancer research , biology , medicine , genetics , pathology , biochemistry

Despite common belief, accumulation of molecular damage does not play a key role in aging. Still, cancer (an age-related disease) is initiated by molecular damage. Cancer and aging share a lot in common including the activation of the TOR pathway. But the role of molecular damage distinguishes cancer and aging. Furthermore, an analysis of the role of both damage and aging in cancer argues against "a decline, caused by accumulation of molecular damage" as a cause of aging. I also discuss how random molecular damage, via rounds of multiplication and selection, brings about non-random hallmarks of cancer.

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