Open AccessInterference between PARPs and SIRT1: a novel approach to healthy ageing?
Author(s) -
Carles Cantó,
Johan Auwerx
Publication year - 2011
Publication title -
aging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.473
H-Index - 90
ISSN - 1945-4589
DOI - 10.18632/aging.100326
Subject(s) - longevity , dna repair , computational biology , biology , rna interference , polymerase , genetics , bioinformatics , dna , rna , gene
Poly(ADP-ribosyl) polymerases (PARPs) have traditionally been linked to chromosome maintenance and DNA repair. Recent findings identify PARPs as key modulators of metabolism through their influence on SIRT1 activity, hinting to a possible role of PARPs as longevity regulators.
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