Insights from model organisms on the functions of the tumor suppressor protein LKB1: Zebrafish chips in | Zendy

Yme U. van der Velden | Zendy; Anna-Pavlina G. Haramis | Zendy

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Insights from model organisms on the functions of the tumor suppressor protein LKB1: Zebrafish chips in

Author(s) -

Yme U. van der Velden,

Anna-Pavlina G. Haramis

Publication year - 2011

Publication title -

aging

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.473

H-Index - 90

ISSN - 1945-4589

DOI - 10.18632/aging.100319

Subject(s) - zebrafish , suppressor , effector , regulator , context (archaeology) , biology , microbiology and biotechnology , model organism , cell metabolism , computational biology , cell , genetics , cancer , gene , paleontology

The tumor suppressor LKB1 has emerged as a critical regulator of cell polarity and energy‐metabolism. Studies in diverse model organisms continue to unravel the pathways downstream of LKB1; the emerging picture is that the outcomes of LKB1 signaling are mediated by a plethora of tissue‐specific and context‐dependent effectors.

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