Open AccessThe physiological roles of Sirt1 in skeletal muscle
Author(s) -
Patricia S. Pardo,
Aladin M. Boriek
Publication year - 2011
Publication title -
aging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.473
H-Index - 90
ISSN - 1945-4589
DOI - 10.18632/aging.100312
Subject(s) - skeletal muscle , inflammation , oxidative stress , function (biology) , endocrinology , medicine , biology , physiology , microbiology and biotechnology
Skeletal muscle aging is associated with increased inflammation and oxidative stress, a decrease in the ability to rebuild muscle after injury and in response to exercise. In this perspective, we discuss the mechanisms regulating Sirt1 activity and expression in skeletal muscles, emphasizing their implications in muscle physiology and the impairment of muscle function with age.
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