The implication of Sir2 in replicative aging and senescence in Saccharomyces cerevisiae | Zendy

Cheol Woong Ha | Zendy; WonKi Huh | Zendy

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The implication of Sir2 in replicative aging and senescence in Saccharomyces cerevisiae

Author(s) -

Cheol Woong Ha,

WonKi Huh

Publication year - 2011

Publication title -

aging

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.473

H-Index - 90

ISSN - 1945-4589

DOI - 10.18632/aging.100299

Subject(s) - saccharomyces cerevisiae , senescence , regulator , biology , longevity , sumo protein , microbiology and biotechnology , telomere , cell growth , genetics , dna , gene , ubiquitin

The target of rapamycin (TOR) pathway regulates cell growth and aging in various organisms. In Saccharomyces cerevisiae, silent information regulator 2 (Sir2) modulates cellular senescence. Moreover, Sir2 plays a crucial role in promoting ribosomal DNA (rDNA) stability and longevity under TOR inhibition. Here we review the implication of rDNA stabilizers in longevity, discuss how Sir2 stabilizes rDNA under TOR inhibition and speculate on the link between sumoylation and Sir2-related pro-aging pathways.

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