Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging | Zendy

Linda S. Steelman | Zendy; William H. Chappell | Zendy; Stephen L. Abrams | Zendy; Christian Kempf | Zendy; Jacquelyn M. Long | Zendy; Piotr Laidler | Zendy; Sanja Mijatović | Zendy; Danijelа Maksimović-Ivanić | Zendy; Franca Stivala | Zendy; María Clorinda Mazzarino | Zendy; Marco Donia | Zendy; Paolo Fagone | Zendy; Graziella Malaponte | Zendy; Ferdinando Nicoletti | Zendy; Massimo Libra | Zendy; Michèle Milella | Zendy; Agostino Tafuri | Zendy; Antonio Bonati | Zendy; Jörg Bäsecke | Zendy; Lucio Cocco | Zendy; Camilla Evangelisti | Zendy; Alberto M. Martelli | Zendy; Giuseppe Montalto | Zendy; Melchiorre Cervello | Zendy; James A. McCubrey | Zendy

Open Access

Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging

Author(s) -

Linda S. Steelman,

William H. Chappell,

Stephen L. Abrams,

Christian Kempf,

Jacquelyn M. Long,

Piotr Laidler,

Sanja Mijatović,

Danijelа Maksimović-Ivanić,

Franca Stivala,

María Clorinda Mazzarino,

Marco Donia,

Paolo Fagone,

Graziella Malaponte,

Ferdinando Nicoletti,

Massimo Libra,

Michèle Milella,

Agostino Tafuri,

Antonio Bonati,

Jörg Bäsecke,

Lucio Cocco,

Camilla Evangelisti,

Alberto M. Martelli,

Giuseppe Montalto,

Melchiorre Cervello,

James A. McCubrey

Publication year - 2011

Publication title -

aging

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.473

H-Index - 90

ISSN - 1945-4589

DOI - 10.18632/aging.100296

Subject(s) - pten , pi3k/akt/mtor pathway , mapk/erk pathway , protein kinase b , cancer research , signal transduction , biology , crosstalk , microbiology and biotechnology , physics , optics

Dysregulated signaling through the Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways is often the result of genetic alterations in critical components in these pathways or upstream activators. Unrestricted cellular proliferation and decreased sensitivity to apoptotic-inducing agents are typically associated with activation of these pro-survival pathways. This review discusses the functions these pathways have in normal and neoplastic tissue growth and how they contribute to resistance to apoptotic stimuli. Crosstalk and commonly identified mutations that occur within these pathways that contribute to abnormal activation and cancer growth will also be addressed. Finally the recently described roles of these pathways in cancer stem cells, cellular senescence and aging will be evaluated. Controlling the expression of these pathways could ameliorate human health.

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