Regulation of life span by mitochondrial respiration: the HIF-1 and ROS connection | Zendy

Ara B. Hwang | Zendy; SeungJae Lee | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Regulation of life span by mitochondrial respiration: the HIF-1 and ROS connection

Author(s) -

Ara B. Hwang,

SeungJae Lee

Publication year - 2011

Publication title -

aging

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.473

H-Index - 90

ISSN - 1945-4589

DOI - 10.18632/aging.100292

Subject(s) - respiration , life span , longevity , reactive oxygen species , mitochondrion , biology , cellular respiration , mutant , hypoxia (environmental) , microbiology and biotechnology , oxygen , mitochondrial ros , biochemistry , chemistry , genetics , botany , evolutionary biology , gene , organic chemistry

A mild reduction in mitochondrial respiration extends the life span of many species, including C. elegans. We recently showed that hypoxia-inducible factor 1 (HIF-1) is required for the acquisition of a long life span by mutants with reduced respiration in C. elegans. We suggested that increased levels of reactive oxygen species (ROS) produced in the respiration mutants increase HIF-1 activity and lead to this longevity. In this research perspective, we discuss our findings and recent advances regarding the roles of ROS and HIF-1 in aging, focusing on the longevity caused by reduced respiration.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research