SirT1 brings stemness closer to cancer and aging | Zendy

Vincenzo Calvanese | Zendy; Mario F. Fraga | Zendy

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SirT1 brings stemness closer to cancer and aging

Author(s) -

Vincenzo Calvanese,

Mario F. Fraga

Publication year - 2011

Publication title -

aging

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.473

H-Index - 90

ISSN - 1945-4589

DOI - 10.18632/aging.100272

Subject(s) - sirtuin , sirtuin 1 , regulator , histone , chromatin , cancer , stem cell , biology , cancer stem cell , microbiology and biotechnology , cancer research , genetics , acetylation , downregulation and upregulation , gene

Sirtuin 1 acts in various cell processes, deacetylating both chromatin and non-histone proteins, and its role in cancer and aging has long been studied and debated. Here we discuss another aspect of SirT1 biology, its function as a stem cell pluripotency and differentiation regulator. We evaluate the implications of these findings in sirtuin inhibition-based cancer treatment and in the application of sirtuin activation for anti-aging therapy.

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