STAT3, HIF-1, glucose addiction and Warburg effect | Zendy

James Darnell | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

STAT3, HIF-1, glucose addiction and Warburg effect

Author(s) -

James Darnell

Publication year - 2010

Publication title -

aging

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.473

H-Index - 90

ISSN - 1945-4589

DOI - 10.18632/aging.100239

Subject(s) - signal transduction , cancer research , jak stat signaling pathway , phosphorylation , stat3 , tyrosine phosphorylation , biology , kinase , tyrosine kinase , tyrosine kinase 2 , cancer , receptor tyrosine kinase , stat , socs3 , microbiology and biotechnology , receptor , biochemistry , genetics , growth factor , platelet derived growth factor receptor

Oncogenes as the center of cancer research focused attention 30 years ago on signal transduction especially tyrosine phosphorylation. Discovery that the Jun oncoprotein was a site-specific DNA binding protein demanded a connection of signaling abnormalities with transcriptional control [1]. The cytokine responsive Jak-STAT pathway, discovered through studying α-interferon activation of STATs 1 and 2 by the Jak tyrosine kinases (Tyk2, Jak1, Jak2) was soon broadened to include the other five STATs [2]. The first description of STAT3 in 1994 [3] raised suspicion in the direction of cancer because IL-6 and EGF, already recognized to have cancer connections, were the originally recognized ligands that activated the STAT3 homodimer.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research