Open AccessP53 levels govern the choice between senescence and quiescence
Author(s) -
David W. Meek
Publication year - 2010
Publication title -
aging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.473
H-Index - 90
ISSN - 1945-4589
DOI - 10.18632/aging.100212
Subject(s) - senescence , cellular senescence , biology , microbiology and biotechnology , psychology , genetics , phenotype , gene
The mechanism(s) by which p53 chooses between outcomes of senescence or quiescence has remained elusive. A paper published in the recent issue of Cell Cycle indicates that this decision may be determined by p53 levels and their ability to selectively down-regulate mTOR signaling.
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