TP53 and MTOR crosstalk to regulate cellular senescence | Zendy

Lorenzo Galluzzi | Zendy; Oliver Kepp | Zendy; Guido Kroemer | Zendy

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TP53 and MTOR crosstalk to regulate cellular senescence

Author(s) -

Lorenzo Galluzzi,

Oliver Kepp,

Guido Kroemer

Publication year - 2010

Publication title -

aging

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.473

H-Index - 90

ISSN - 1945-4589

DOI - 10.18632/aging.100202

Subject(s) - pi3k/akt/mtor pathway , regulator , crosstalk , senescence , suppressor , microbiology and biotechnology , negative regulator , master regulator , biology , cellular senescence , cancer research , signal transduction , genetics , engineering , phenotype , transcription factor , cancer , gene , electronic engineering

The full spectrum of activities of the tumor suppressor p53 (TP53) has not been completely elucidated yet. Recently, it was demonstrated that TP53 communicates with the metabolic regulator mechanistic target of rapamycin (MTOR) to determine whether stressed cells undergo cell death, reversible quiescence or irreversible senescence, thereby adding yet another level of complexity to the signaling network that emanate from TP53.

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