P66SHC and Ageing: ROS and TOR? | Zendy

Giovambattista Pani | Zendy

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P66SHC and Ageing: ROS and TOR?

Author(s) -

Giovambattista Pani

Publication year - 2010

Publication title -

aging

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.473

H-Index - 90

ISSN - 1945-4589

DOI - 10.18632/aging.100182

Subject(s) - calorie restriction , reactive oxygen species , p70 s6 kinase 1 , nutrient sensing , ageing , hyperactivation , pi3k/akt/mtor pathway , microbiology and biotechnology , insulin resistance , biology , mtorc1 , insulin , signal transduction , endocrinology , genetics

Both Reactive Oxygen Species (ROS) and hyperactivation of the nutrient-sensing mTOR/S6 kinase cascade have been linked to aging and age-related diseases as well as to the anti-aging effect of calorie restriction. Recent findings that the pro-aging and pro-oxidant molecule p66shc contributes to S6K activation by nutrients and promotes insulin resistance and diabetes in mice may provide an answer to the "ROS or TOR?" dilemma.

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