Open AccessHuman insulin/IGF-1 and familial longevity at middle age
Author(s) -
Maarten Pieter Rozing,
Rudi G. J. Westendorp,
Marijke Frölich,
Anton J.M. de Craen,
Marian Beekman,
Bastiaan T. Heijmans,
Simon P. Mooijaart,
Gerard J. Blauw,
P. Eline Slagboom,
Diana van Heemst,
on behalf of the Leiden Longevity Study Group
Publication year - 2009
Publication title -
aging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.473
H-Index - 90
ISSN - 1945-4589
DOI - 10.18632/aging.100071
Subject(s) - longevity , igfbp3 , offspring , medicine , diabetes mellitus , insulin , endocrinology , biology , insulin receptor , genetics , insulin resistance , receptor , growth factor , pregnancy
Recently, we have shown that compared to controls, long-lived familial nonagenarians (mean age: 93.4 years) from the Leiden Longevity Study displayed a lower mortality rate, and their middle-aged offspring displayed a lower prevalence of cardio-metabolic diseases, including diabetes mellitus. The evolutionarily conserved insulin/IGF-1 signaling (IIS) pathway has been implicated in longevity in model organisms, but its relevance for human longevity has generated much controversy. Here, we show that compared to their partners, the offspring of familial nonagenarians displayed similar non-fasted serum levels of IGF-1, IGFBP3 and insulin but lower non-fasted serum levels of glucose, indicating that familial longevity is associated with differences in insulin sensitivity.
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