Open AccessGrowth and aging: a common molecular mechanism
Author(s) -
Mikhail V. Blagosklonny,
Michael N. Hall
Publication year - 2009
Publication title -
aging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.473
H-Index - 90
ISSN - 1945-4589
DOI - 10.18632/aging.100040
Subject(s) - mechanism (biology) , biology , microbiology and biotechnology , epistemology , philosophy
It is commonly assumed that growth and aging are somehow linked, but the nature of this link has been elusive. Here we review the aging process as a continuation of TOR-driven growth. TOR is absolutely essential for developmental growth, but upon completion of development it causes aging and age-related diseases. Thus, the nutrient-sensing and growth-promoting TOR signaling pathway may provide a molecular link between growth and aging that is universal from yeast to human.
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