Anti-aging protein SIRT1: A role in cervical cancer? | Zendy

Christopher Brooks | Zendy; Wei Gu | Zendy

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Anti-aging protein SIRT1: A role in cervical cancer?

Author(s) -

Christopher Brooks,

Wei Gu

Publication year - 2009

Publication title -

aging

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.473

H-Index - 90

ISSN - 1945-4589

DOI - 10.18632/aging.100031

Subject(s) - sirtuin , effector , microbiology and biotechnology , transcription factor , sirtuin 1 , histone deacetylase , nad+ kinase , ku70 , histone , epigenetics , dna damage , biology , sirt2 , histone deacetylase 2 , senescence , dna repair , acetylation , dna , genetics , biochemistry , gene , downregulation and upregulation , enzyme

The sirtuin protein SIRT1 is a well studied and highly complex NAD+ dependent class III histone deacetylase that has seemingly diverse functions in metabolism, aging and cancer. SIRT1 deacetylates several downstream effector proteins including KU70, NBS1, the FOXO transcription factor family, and p53, several of which are in response to DNA damage events occurring within the cell [1]. Regulation of these factors by SIRT1 has indicated its direct role in cell growth and cellular senescence, and recent advances in understanding the physiologic nature of SIRT1 in these processes have posited both growth-promoting and grow-inhibiting effects of the protein.

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