Study on the preparation and drug release property of Modified PEG-DA based hydrogels | Zendy

Şebnem Şenol Akar | Zendy; Emel Akyol | Zendy

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Study on the preparation and drug release property of Modified PEG-DA based hydrogels

Author(s) -

Şebnem Şenol Akar,

Emel Akyol

Publication year - 2019

Publication title -

journal of the turkish chemical society section a chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.179

H-Index - 6

ISSN - 2149-0120

DOI - 10.18596/jotcsa.485817

Subject(s) - self healing hydrogels , photopolymer , fourier transform infrared spectroscopy , peg ratio , materials science , scanning electron microscope , swelling , chemical engineering , nuclear chemistry , acetophenone , polymer chemistry , chemistry , organic chemistry , polymer , composite material , polymerization , catalysis , engineering , economics , finance

The aim of the present study is to develop hydroxyapatite modified PEG-DA and PEG-DA/HEMA based hydrogels for release of Donepezil HCl for potential treatment of Alzheimer’s disease. [2,2-Dimethoxy-2-phenyl-acetophenone] (Irgacure 651), 1 Hydroxycyclohexyl phenyl ketone (Irgacure 184) and 2-Hydroxy-4'-(2-hydroxyethoxy)-2-methylpropiophenone (Irgacure 2959) were used as photo-initiators in the synthesis of hydrogels and hydroxyapatite was used for modifying hydrogels. Fourier transform infrared spectroscopy (FT-IR), scanning electron microscope (SEM) and digital microscope were utilized to investigate the characteristics properties of hydrogels. Photopolymerization technique was selected to synthesize for hydrogels. Swelling and drug release studies have been performed under different pH conditions.

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