Synthesis of Some New Benzimidazole Derivatives Containing Chlorine and Investigation of Their Antioxidant and Anti-urease Activities

In this work, the synthesis of 2-substituted benzimidazole compound containing chlorine ( 1 ) was carried out and then converted to the ester (2) and hydrazide (3) derivatives respectively. In the next steps, the hydrazide compound ( 3 ) was reacted with the appropriate reagents to give the thiadiazole ( 8-10 ) and triazole ( 11-13 ) derivatives. Synthesis of the compound 4 was carried out as a result of the interaction of the ester derivative compound ( 2 ) with morpholine. The structures of all synthesized compounds were elucidated by FT-IR, 1 H NMR, 13 C NMR and elemental analysis spectroscopic methods. Also, the antioxidant and urease enzyme inhibition properties of these compounds were also investigated.