Adsorption Of Metamizole Sodium By Activated Carbon In Simulated Gastric And Intestinal Fluids | Zendy

Elif Çalışkan Salihi | Zendy

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Adsorption Of Metamizole Sodium By Activated Carbon In Simulated Gastric And Intestinal Fluids

Author(s) -

Elif Çalışkan Salihi

Publication year - 2017

Publication title -

journal of the turkish chemical society section a chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.179

H-Index - 6

ISSN - 2149-0120

DOI - 10.18596/jotcsa.353590

Subject(s) - adsorption , activated carbon , langmuir equation , chemistry , sodium , langmuir adsorption model , langmuir , chromatography , metamizole , gastric fluid , carbon fibers , materials science , organic chemistry , medicine , composite material , analgesic , composite number , pharmacology

In vitro adsorption of metamizole sodium by activated carbon was studied at pH 1.2 and 7.5 in order to simulate gastric and intestinal fluids. In the first 5 minutes, more than eighty percent of the total adsorption occurred but the adsorption process achieved to the equilibrium in 1 hour. Time to reach equilibrium was not changed with the changing pH, concentration of the adsorbate or the adsorbent amount. The equilibrium data followed the Langmuir model and therefore fitted to L-type in accordance with the Giles classification for adsorption isotherms. The maximum removal capacities of the activated carbon for metamizole sodium were calculated using Langmuir equation and found as 185.19 mg/g and 161.29 mg/g at pH 1.2 and 7.5, respectively.

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