Novel metal complexes of mixed piperaquine-acetaminophen and piperaquine-acetylsalicylic acid: Synthesis, characterization and antimicrobial activities | Zendy

Yusuf Oloruntoyin Ayipo | Zendy; Joshua A. Obaleye | Zendy; Umar Muhammad Badeggi | Zendy

Open Access

Novel metal complexes of mixed piperaquine-acetaminophen and piperaquine-acetylsalicylic acid: Synthesis, characterization and antimicrobial activities

Author(s) -

Yusuf Oloruntoyin Ayipo,

Joshua A. Obaleye,

Umar Muhammad Badeggi

Publication year - 2016

Publication title -

journal of the turkish chemical society section a chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.179

H-Index - 6

ISSN - 2149-0120

DOI - 10.18596/jotcsa.287331

Subject(s) - cobalt , chemistry , zinc , stoichiometry , melting point , atomic absorption spectroscopy , nuclear chemistry , inorganic chemistry , nickel , copper , organic chemistry , physics , quantum mechanics

Synthesis of coordination compounds of Zinc(II), Copper(II), Nickel(II), Cobalt(II) and Iron(II) with mixed piperaquine-acetaminophen and piperaquine-acetylsalicylic acid has been studied. The complexes were characterized via: solubility test, melting point determination, conductivity measurement, Atomic Absorption Spectroscopy, UV-Visible Spectroscopy, FTIR Spectroscopy and magnetic susceptibility. The complexes were proposed to have a stoichiometry ratio of 1:1:1 between each metal salt and the ligands with tetrahedral and octahedral geometry following the reaction pattern of MX.yH 2 O + L 1 L 2/3 to give ML 1 L 2/3 X.yH 2 O. Biologica l activities of the synthesized complexes have been evaluated against Escherichia coli and Staphylococcus aureus .

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