Extensive ERG11 mutations associated with fluconazole-resistant Candida albicans isolated from HIV-infected patients | Zendy

Sony Paul | Zendy; Iyanar Kannan | Zendy; Kalyani Mohanram | Zendy

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Extensive ERG11 mutations associated with fluconazole-resistant Candida albicans isolated from HIV-infected patients

Author(s) -

Sony Paul,

Iyanar Kannan,

Kalyani Mohanram

Publication year - 2019

Publication title -

current medical mycology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.369

H-Index - 6

eISSN - 2423-3439

pISSN - 2423-3420

DOI - 10.18502/cmm.5.3.1739

Subject(s) - fluconazole , candida albicans , nonsense mutation , microbiology and biotechnology , genotyping , candida tropicalis , biology , azole , agar dilution , candida glabrata , polymerase chain reaction , medicine , gene , mutation , missense mutation , minimum inhibitory concentration , genotype , antifungal , antibiotics , genetics

Azoles are preferred antifungal agents given their inexpensiveness, limited toxicity, and potentiality of oral administration. However, the extensive use of prophylactic azole therapy for chronic infections, especially in immunocompromised patients, has led to an increase in azole resistance, thereby rising health care costs. Fluconazole resistance is associated with poor clinical outcomes and the emergence of new infections. The present study aimed to investigate the mutations of ERG11 gene in fluconazole-resistant Candida albicans isolates.

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