siRNA Delivery Technology for Cancer Therapy: Promise and Challenges | Zendy

Fateme Karimi Dermani | Zendy; Farid Azizi Jalilian | Zendy; H. Hossienkhani | Zendy; Razieh Ezati | Zendy; Razieh Amini | Zendy

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siRNA Delivery Technology for Cancer Therapy: Promise and Challenges

Author(s) -

Fateme Karimi Dermani,

Farid Azizi Jalilian,

H. Hossienkhani,

Razieh Ezati,

Razieh Amini

Publication year - 2019

Publication title -

acta medica iranica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.218

H-Index - 27

eISSN - 1735-9694

pISSN - 0044-6025

DOI - 10.18502/acta.v57i2.1760

Subject(s) - medicine , small interfering rna , gene silencing , nuclease , rna interference , genetic enhancement , cancer , computational biology , cancer therapy , bioinformatics , rna , gene , biology , biochemistry

Small interfering RNAs (siRNA) technology has shown great promise as a new class of therapeutic interventions for the treatment of cancer and other diseases. It is a remarkable endogenous pathway that can regulate sequence-specific gene silencing. Despite the excitement about possible applications of this biological process for sequence-specific gene regulation, the major limitations against the use of siRNA-based therapeutics are their rapid degradation by serum nuclease, poor cellular uptake, and rapid renal clearance following systemic delivery, off-target effects and the induction of immune responses. Many researchers have tried to overcome these limitations by developing nuclease-resistant chemically-modified siRNAs and a variety of synthetic and natural biodegradable lipids and polymers to enhance the efficacy and safety profiles of siRNA delivery. Ideal siRNA-based delivery systems for cancer therapy must be clinically suitable, safe and effective. In this review, we introduce the greatest challenges in achieving efficient RNAi delivery and discuss design criteria and various delivery strategies for cancer therapy, including chemical modifications, lipid-based nano-vectors, polymer-mediated delivery systems, conjugate delivery systems, and others. © 2019 Tehran University of Medical Sciences. All rights reserved.

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