Synthesis and Study of 1,2,4-Triazine and Thiadiazoles Based Derivatives of S-Triazine as Antimicrobial Agents | Zendy

G. M. Malik | Zendy; Talha V. Patel | Zendy

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Synthesis and Study of 1,2,4-Triazine and Thiadiazoles Based Derivatives of S-Triazine as Antimicrobial Agents

Author(s) -

G. M. Malik,

Talha V. Patel

Publication year - 2017

Publication title -

journal of asian scientific research

Language(s) - English

Resource type - Journals

eISSN - 2226-5724

pISSN - 2223-1331

DOI - 10.18488/journal.2.2017.76.214.223

Subject(s) - antimicrobial , triazine , gram , amine gas treating , chemistry , thiadiazoles , proton nmr , 1,3,5 triazine , in vitro , combinatorial chemistry , organic chemistry , nuclear chemistry , bacteria , biochemistry , biology , genetics

Some new substituted 1,3,5 triazine derivatives with 4-amino-6-(tert-butyl)-3-(methylthio)-1,2,4-triazin-5(4H)-one and 5-benzyl-1,3,4-thiadiazol-2-amine and primary amine were synthesized and evaluated for their in vitro antimicrobial activity against Gram positive and Gram negative strains using a micro dilution procedure. Synthesized compounds P1BF to P15BF prove to be effective with MIC ( g/mL), among them P2BF, P6BF, P15BF showed excellent activity against a panel of microorganisms. The newly synthesized compounds were characterized using IR, 1H-NMR, 13CNMR, MASS Analysis.

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