Open AccessMicrodialysis-directed Intra-tumor Pharmacokinetic Modeling of Methotrexate in Mice and Humans
Author(s) -
Helal H. Alsulimani,
Jonghan Kim,
Shabnam N. Sani
Publication year - 2016
Publication title -
journal of pharmacy and pharmaceutical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.497
H-Index - 78
ISSN - 1482-1826
DOI - 10.18433/jpps.v19i2.26074
Subject(s) - pharmacokinetics , microdialysis , methotrexate , chemistry , interstitial fluid , pharmacology , pathology , medicine , extracellular , biochemistry
To develop a quantitative pharmacokinetic model to characterize the disposition of methotrexate (MTX) at tumor site in tumor-bearing mice and to predict MTX concentrations in the human tumor.
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