Coamorphous Atorvastatin Calcium to Improve its Physicochemical and Pharmacokinetic Properties | Zendy

Ali Shayanfar | Zendy; Hamed Ghavimi | Zendy; Hamed Hamishekar | Zendy; Abolghasem Jouyban | Zendy

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Coamorphous Atorvastatin Calcium to Improve its Physicochemical and Pharmacokinetic Properties

Author(s) -

Ali Shayanfar,

Hamed Ghavimi,

Hamed Hamishekar,

Abolghasem Jouyban

Publication year - 2013

Publication title -

journal of pharmacy and pharmaceutical sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.497

H-Index - 78

ISSN - 1482-1826

DOI - 10.18433/j3xs4s

Subject(s) - solubility , dissolution , differential scanning calorimetry , amorphous solid , bioavailability , chemistry , biopharmaceutics classification system , nuclear chemistry , chromatography , materials science , chemical engineering , pharmacology , organic chemistry , medicine , thermodynamics , engineering , physics

Atorvastatin calcium (ATC) is classified as class II (low solubility and high permeability) compound according to the biopharmaceutical classification system. The amorphous form of ATC possesses higher solubility, dissolution rate, and bioavailability than its crystalline form. Coamorphous drug system is a new and emerging method to prepare stable amorphous forms, in this case leading to the improved stability of ATC in dissolution medium.

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