Quantitative Structure – Pharmacokinetics Relationships Analysis of Basic Drugs: Volume of Distribution | Zendy

Zvetanka Zhivkova | Zendy; Tsvetelina Mandova | Zendy; Irini Doytchinova | Zendy

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Quantitative Structure – Pharmacokinetics Relationships Analysis of Basic Drugs: Volume of Distribution

Author(s) -

Zvetanka Zhivkova,

Tsvetelina Mandova,

Irini Doytchinova

Publication year - 2015

Publication title -

journal of pharmacy and pharmaceutical sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.497

H-Index - 78

ISSN - 1482-1826

DOI - 10.18433/j3xc7s

Subject(s) - pharmacokinetics , stepwise regression , volume of distribution , lipophilicity , linear regression , distribution (mathematics) , regression analysis , mathematics , pharmacology , computer science , econometrics , statistics , chemistry , medicine , stereochemistry , mathematical analysis

The early prediction of pharmacokinetic behavior is of paramount importance for saving time and resources and for increasing the success of new drug candidates. The steady-state volume of distribution (VDss) is one of the key pharmacokinetic parameters required for the design of a suitable dosage regimen. The aim of the study is to propose a quantitative structure - pharmacokinetics relationships (QSPkR) for VDss of basic drugs.

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