Review of Pharmaceutical Applications of N-Methyl-2-Pyrrolidone | Zendy

Abolghasem Jouyban | Zendy; Mohammad A. A. Fakhree | Zendy; Ali Shayanfar | Zendy

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Review of Pharmaceutical Applications of N-Methyl-2-Pyrrolidone

Author(s) -

Abolghasem Jouyban,

Mohammad A. A. Fakhree,

Ali Shayanfar

Publication year - 2010

Publication title -

journal of pharmacy and pharmaceutical sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.497

H-Index - 78

ISSN - 1482-1826

DOI - 10.18433/j3p306

Subject(s) - solvent , toxicity , solubilization , chemistry , pharmaceutical industry , active ingredient , organic chemistry , pharmacology , medicine , biochemistry

N-Methyl-2-pyrrolidone (NMP) or Pharmasolve is very strong solubilizing agent and it has important applications in different fields of industry. This review presents NMP physicochemical characteristics, application especially in pharmaceutical sciences, pharmacokinetic and toxicity. Characteristics of NMP such as physicochemical properties, solubilization efficacy, toxicity and adverse effects were compared with other common solvents used in the pharmaceutical industries. This review reveals that NMP is an acceptable pharmaceutical solvent and its efficacy, toxicity, and side effects are comparable with other common solvent.

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