Pharmacokinetics and Pharmacodynamics of diclofenac in the presence and absence of glibenclamide in the rat | Zendy

María R. León-Reyes | Zendy; Gilberto CastañedaHernández | Zendy; Mario I. Ortíz | Zendy

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Pharmacokinetics and Pharmacodynamics of diclofenac in the presence and absence of glibenclamide in the rat

Author(s) -

María R. León-Reyes,

Gilberto CastañedaHernández,

Mario I. Ortíz

Publication year - 2016

Publication title -

journal of pharmacy and pharmaceutical sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.497

H-Index - 78

ISSN - 1482-1826

DOI - 10.18433/j3ks39

Subject(s) - glibenclamide , diclofenac , pharmacology , pharmacokinetics , analgesic , bioavailability , pharmacodynamics , oral administration , medicine , nociception , drug interaction , endocrinology , receptor , diabetes mellitus

There are evidences that glibenclamide, a sulfonylurea antidiabetic agent, reduces the analgesic action of non-steroidal antiinflammatory drugs (NSAIDs), opioids and neuromodulators in animal models. The purpose of this work was to examine in the rat if such interaction involves pharmacokinetic mechanisms or is solely limited to the pharmacodynamic level.

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