Nasal Delivery of Recombinant Human Growth Hormone: In Vivo Evaluation with Pheroid™ Technology and N-Trimethyl Chitosan Chloride | Zendy

Dewald Steyn | Zendy; Du Plessis | Zendy; Awie F. Kotzé | Zendy

Open Access

Nasal Delivery of Recombinant Human Growth Hormone: In Vivo Evaluation with Pheroid™ Technology and N-Trimethyl Chitosan Chloride

Author(s) -

Dewald Steyn,

Du Plessis,

Awie F. Kotzé

Publication year - 2010

Publication title -

journal of pharmacy and pharmaceutical sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.497

H-Index - 78

ISSN - 1482-1826

DOI - 10.18433/j3cs3f

Subject(s) - bioavailability , nasal administration , chitosan , in vivo , pharmacology , absorption (acoustics) , chemistry , pulmonary surfactant , vesicle , biochemistry , medicine , biology , materials science , microbiology and biotechnology , composite material , membrane

It was the aim of this study to investigate the possible enhancement of the absorption of recombinant human growth hormone (rhGH) in the nasal cavity, in the presence of a polymeric absorption enhancer, N-trimethyl chitosan chloride (TMC) and a fatty acid-based delivery system, Pheroid.

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