Drug Discovery Inspired by Mother Nature: Seeking Natural Biochemotypes and the Natural Assembly Rules of the Biochemome
Author(s) -
Qiong Gu,
Xin Yan,
Jun Xu
Publication year - 2013
Publication title -
journal of pharmacy and pharmaceutical sciences
Language(s) - English
Resource type - Journals
ISSN - 1482-1826
DOI - 10.18433/j3c31s
Subject(s) - drug discovery , natural (archaeology) , set (abstract data type) , table (database) , natural product , computational biology , computer science , chemical space , organism , data science , combinatorial chemistry , biology , chemistry , bioinformatics , data mining , genetics , biochemistry , paleontology , programming language
The Human Genome Project is producing a new biological 'periodic table', which defines all genes for making macromolecules (proteins, DNA, RNA, etc) and the relations between genes and their biological functions. We now need to consider whether to initiate a biochemome project aimed at discovering biochemistry's 'periodic table', which would define all molecular parts for making small molecules (natural products) and the relations between the parts and their functions to regulate genes. By understanding the Biochemome, we might be able to design biofunctional molecules based upon a set of molecular parts for drug innovation.
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