Karanjin interferes with ABCB1, ABCC1, and ABCG2 | Zendy

Martin Michaelis | Zendy; Florian Rothweiler | Zendy; Thomas Nerreter | Zendy; Mohsen Sharifi | Zendy; Taravat Ghafourian | Zendy; Jindřich Činátl | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Karanjin interferes with ABCB1, ABCC1, and ABCG2

Author(s) -

Martin Michaelis,

Florian Rothweiler,

Thomas Nerreter,

Mohsen Sharifi,

Taravat Ghafourian,

Jindřich Činátl

Publication year - 2014

Publication title -

journal of pharmacy and pharmaceutical sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.497

H-Index - 78

ISSN - 1482-1826

DOI - 10.18433/j3bw2s

Subject(s) - traditional medicine , abcg2 , medicine , chemistry , atp binding cassette transporter , biochemistry , transporter , gene

The prominent ATP-binding cassette (ABC) transporters ABCB1, ABCC1, and ABCG2 are involved in substance transport across physiological barriers and therefore in drug absorption, distribution, and elimination. They also mediate multi-drug resistance in cancer cells. Different flavonoids are known to interfere with different ABC transporters. Here, the effect of the furanoflavonol karanjin, a potential drug with antiglycaemic, gastroprotective, antifungal, and antibacterial effects, was investigated on ABCB1, ABCC1, and ABCG2-mediated drug transport in comparison to the flavonoids apigenin, genistein, and naringenin.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research