Mechanism of Dissolution Enhancement and Bioavailability of Poorly Water Soluble Celecoxib by Preparing Stable Amorphous Nanoparticles | Zendy

Yinghui Liu | Zendy; Changshan Sun | Zendy; Yanru Hao | Zendy; Tongying Jiang | Zendy; Zheng Li | Zendy; Siling Wang | Zendy

Open Access

Mechanism of Dissolution Enhancement and Bioavailability of Poorly Water Soluble Celecoxib by Preparing Stable Amorphous Nanoparticles

Author(s) -

Yinghui Liu,

Changshan Sun,

Yanru Hao,

Tongying Jiang,

Zheng Li,

Siling Wang

Publication year - 2010

Publication title -

journal of pharmacy and pharmaceutical sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.497

H-Index - 78

ISSN - 1482-1826

DOI - 10.18433/j3530j

Subject(s) - dissolution , nanoparticle , amorphous solid , x ray photoelectron spectroscopy , chemical engineering , materials science , differential scanning calorimetry , solubility , chemistry , nuclear chemistry , organic chemistry , nanotechnology , physics , engineering , thermodynamics

Nanoparticle engineering offers promising methods for the formulation of poorly water soluble drug compounds. The aim of the present work was to enhance dissolution and oral bioavailability of poorly water-soluble celecoxib (CXB) by preparing stable CXB nanoparticles using a promising method, meanwhile, investigate the mechanism of increasing dissolution of CXB.

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