Effects of Long-Term Hepatic Ischemia-Reperfusion Injury on the Function of P-glycoprotein in vivo in Rats | Zendy

Camilla A. Thorling | Zendy; Michael S. Roberts | Zendy; Xin Liu | Zendy; Linda Fletcher | Zendy; Dorothy H. Crawford | Zendy; Frank J. Burczynski | Zendy

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Effects of Long-Term Hepatic Ischemia-Reperfusion Injury on the Function of P-glycoprotein in vivo in Rats

Author(s) -

Camilla A. Thorling,

Michael S. Roberts,

Xin Liu,

Linda Fletcher,

Dorothy H. Crawford,

Frank J. Burczynski

Publication year - 2014

Publication title -

journal of pharmacy and pharmaceutical sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.497

H-Index - 78

ISSN - 1482-1826

DOI - 10.18433/j33c7b

Subject(s) - in vivo , reperfusion injury , ischemia , hepatic function , medicine , term (time) , function (biology) , glycoprotein , pharmacology , cardiology , chemistry , biology , microbiology and biotechnology , biochemistry , physics , quantum mechanics

Ischemia-reperfusion injury is a common complication in liver surgery with oxidative stress related graft failure as a potential complication. The oxidative stress could affect hepatic drug transporters such as P-glycoprotein, which is crucial in the hepatic clearance of certain immunosuppressant drugs. Thus,, it is important to study its function after ischemia-reperfusion injury in vivo. Rhodamine 123 is a fluorescent substrate of P-glycoprotein and its hepatic disposition can be visualized using multiphoton microscopy in vivo using anaesthetized animals. The aim of this study was to investigate the effect of long-term ischemia-reperfusion injury on P-glycoprotein function in hepatocytes using in vivo multiphoton microscopy.

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