Dissolution Enhancement of Gliclazide Using pH Change Approach in Presence of Twelve Stabilizers with Various Physico-Chemical Properties | Zendy

Roya Talari | Zendy; Ali Nokhodchi | Zendy; Seyed Abolfazl Mostafavi | Zendy; Jaleh Varshosaz | Zendy

Open Access

Dissolution Enhancement of Gliclazide Using pH Change Approach in Presence of Twelve Stabilizers with Various Physico-Chemical Properties

Author(s) -

Roya Talari,

Ali Nokhodchi,

Seyed Abolfazl Mostafavi,

Jaleh Varshosaz

Publication year - 2009

Publication title -

journal of pharmacy and pharmaceutical sciences

Language(s) - English

Resource type - Journals

ISSN - 1482-1826

DOI - 10.18433/j31p4p

Subject(s) - gliclazide , dissolution , chemistry , chemical engineering , organic chemistry , medicine , diabetes mellitus , engineering , endocrinology

The micronization using milling process to enhance dissolution rate is extremely inefficient due to a high energy input, and disruptions in the crystal lattice which can cause physical or chemical instability. Therefore, the aim of the present study is to use in situ micronization process through pH change method to produce micron-size gliclazide particles for fast dissolution hence better bioavailability.

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