A New Cytotoxic Steroidal Glycoalkaloid from the Methanol Extract of Blumea lacera Leaves | Zendy

Raushanara Akter | Zendy; Shaikh Jamal Uddin | Zendy; Joe Tiralongo | Zendy; I. Darren Grice | Zendy; Evelin Tiralongo | Zendy

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A New Cytotoxic Steroidal Glycoalkaloid from the Methanol Extract of Blumea lacera Leaves

Author(s) -

Raushanara Akter,

Shaikh Jamal Uddin,

Joe Tiralongo,

I. Darren Grice,

Evelin Tiralongo

Publication year - 2015

Publication title -

journal of pharmacy and pharmaceutical sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.497

H-Index - 78

ISSN - 1482-1826

DOI - 10.18433/j3161q

Subject(s) - glycoalkaloid , chemistry , traditional medicine , methanol , medicine , biochemistry , organic chemistry , solanaceae , gene

Blumea lacera (B. lacera) (Asteraceae) is a well-known Bangladeshi medicinal plant. This study aimed to identify and characterize constituents associated with the significant cytotoxic activity of this plant that we reported previously. Here, we describe the isolation and characterization of a new steroidal glycoalkaloid (SGA) 1, the evaluation of its cytotoxic activity, apoptotic potential, and effect on cell cycle in comparison to analogous steroidal glycoalkaloids (SGAs).

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