Roundup-induced biochemical and histopathological changes in the liver and kidney of rats: the ameliorative effects of Linum usitatissimum oil | Zendy

Nesrine Djaber | Zendy; Lynda Sabrina Ounaceur | Zendy; Baya Nouha Moubine | Zendy; Taha Khaldi | Zendy; Mereim Rouag | Zendy; Salma Berrouague | Zendy; Hichem Amara | Zendy; Faïza Taïbi | Zendy; Mahieddine Boumendjel | Zendy; Amel Boumendjel | Zendy; Mahfoud Messarah | Zendy

Open Access

Roundup-induced biochemical and histopathological changes in the liver and kidney of rats: the ameliorative effects of Linum usitatissimum oil

Author(s) -

Nesrine Djaber,

Lynda Sabrina Ounaceur,

Baya Nouha Moubine,

Taha Khaldi,

Mereim Rouag,

Salma Berrouague,

Hichem Amara,

Faïza Taïbi,

Mahieddine Boumendjel,

Amel Boumendjel,

Mahfoud Messarah

Publication year - 2020

Publication title -

acta biochimica polonica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.452

H-Index - 78

eISSN - 1734-154X

pISSN - 0001-527X

DOI - 10.18388/abp.2020_2898

Subject(s) - linum , oxidative stress , creatinine , antioxidant , chemistry , bilirubin , urea , kidney , dpph , traditional medicine , endocrinology , medicine , pharmacology , biochemistry , biology , botany

The present study was undertaken to evaluate the protective effects of Linum usitatissimum oil (LuO) against sub-chronic Roundup (RDP)-induced toxicity and oxidative stress in rats. Rats were divided into four groups: control group (no treatment), RDP group (Roundup at 269.9 mg/kg b.w.), LuO group (0.5 g/kg b.w. of LuO) and RDP+LuO group (RDP and LuO simultaneously). LuO decreased the ferric reducing antioxidant power (FRAP) (IC50=10.36 μg/ml) and 2,2-diphenyl-1-picrylhydrazyl (DPPH) (IC50=22.85 mg/ml) in the tested tissues. The 30-day exposure of rats to RDP caused an increase in serum hepatic and renal markers: AST, ALT, ALP, LDH, γGT, bilirubin, urea, and creatinine. In addition, SOD, CAT and GST activities decreased by 43%, 61%, and 61%, respectively, while GPx activity, MDA and PCOs levels increased by 80%, 46%, 25%, respectively. LuO treatment alleviated hepatotoxicity in RDP-treated rats, showing improved levels of oxidative stress biomarkers and plasma biochemical parameters. The histological examination of the liver and kidney confirmed the changes in Roundup-treated rats and demonstrated the protective role of LuO.

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