INTRACELLULAR MECHANISMS OF TUMOR CELL IMMUNORESISTANCE | Zendy

Justyna Magdalena Hermanowicz | Zendy; Beata Sieklucka | Zendy; Krzysztof Nosek | Zendy; Dariusz Pawlak | Zendy

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INTRACELLULAR MECHANISMS OF TUMOR CELL IMMUNORESISTANCE

Author(s) -

Justyna Magdalena Hermanowicz,

Beata Sieklucka,

Krzysztof Nosek,

Dariusz Pawlak

Publication year - 2020

Publication title -

acta biochimica polonica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.452

H-Index - 78

eISSN - 1734-154X

pISSN - 0001-527X

DOI - 10.18388/abp.2020_2878

Subject(s) - intracellular , cd80 , immune system , microbiology and biotechnology , t cell , chemistry , cancer research , signal transduction , lymphocyte , function (biology) , biology , immunology , cytotoxic t cell , biochemistry , in vitro , cd40

One of the main mechanisms for avoiding immune response by cancer cells is mediated by inducing an immunosuppressive environment in the tumor following activation of immune checkpoints, i.e. PD-1 or CTLA-4 receptor inhibitors on T lymphocytes. Interaction inhibition between PD-1 or CTLA-4 and their ligands (PD-L1, CD80, and CD85) leads to unblocking of the T-lymphocyte function, and thus destroys cancer cells. Certain intracellular signaling pathways are also involved in the development of tumor cell immunoresistance. Immunosuppressive pathways' activation blocking may increase the immunological anti-tumor control.

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