Mesenchymal stem cells’ homing and cardiac tissue repair | Zendy

Renata Szydlak | Zendy

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Mesenchymal stem cells’ homing and cardiac tissue repair

Author(s) -

Renata Szydlak

Publication year - 2019

Publication title -

acta biochimica polonica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.452

H-Index - 78

eISSN - 1734-154X

pISSN - 0001-527X

DOI - 10.18388/abp.2019_2890

Subject(s) - homing (biology) , mesenchymal stem cell , regenerative medicine , regeneration (biology) , stem cell , stem cell transplantation for articular cartilage repair , medicine , clinical uses of mesenchymal stem cells , microbiology and biotechnology , cancer research , pathology , immunology , biology , adult stem cell , in vitro , endothelial stem cell , ecology , biochemistry

Nowadays, mesenchymal stem cells (MSCs) are essential players in cellular therapy and regenerative medicine. MSCs are used to treat cardiac disorders by intramyocardial injection or injection into the bloodstream. Therefore, a premise of successful MSC-based therapy is that the cells reach the site of injury and home the damaged tissue. In response to inflammatory conditions, MSCs can potentially move into the place of injury and colonize damaged tissues, where they participate in their regeneration. This review presents the current knowledge of the mechanisms of MSCs migration and target tissue homing in the field of cardiovascular therapies.

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