Novel combinatorial transdermal drug delivery of alendronate with risedronate for the treatment of osteoporosis | Zendy

Fanguo Kong | Zendy; Bin Jia | Zendy; Peng Cui | Zendy; Duojun Wang | Zendy

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Novel combinatorial transdermal drug delivery of alendronate with risedronate for the treatment of osteoporosis

Author(s) -

Fanguo Kong,

Bin Jia,

Peng Cui,

Duojun Wang

Publication year - 2019

Publication title -

acta biochimica polonica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.452

H-Index - 78

eISSN - 1734-154X

pISSN - 0001-527X

DOI - 10.18388/abp.2019_2863

Subject(s) - transdermal , drug , osteoporosis , drug delivery , pharmacology , alendronic acid , medicine , chemistry , bisphosphonate , organic chemistry

The presented investigation explores the efficiency of novel transdermal drug delivery system of combination of two drugs i.e risedronate and alendronate in the treatment of osteoporosis. The nanoparticulate transdermal patch was prepared using PLGA as principle polymer which has been found to be suitable for drug delivery. The novel formulation system was found to be more efficient in lowering and maintaining the plasma calcium at a normal level when compared to a pure drug in a study carried out on an excised rat skin.

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