Functional analyses of a low-penetrance risk variant rs6702619/1p21.2 associating with colorectal cancer in Polish population | Zendy

Małgorzata Statkiewicz | Zendy; Natalia Maryan | Zendy; Maria Kulecka | Zendy; Urszula Kuklinska | Zendy; Jerzy Ostrowski | Zendy; Michał Mikula | Zendy

Open Access

Functional analyses of a low-penetrance risk variant rs6702619/1p21.2 associating with colorectal cancer in Polish population

Author(s) -

Małgorzata Statkiewicz,

Natalia Maryan,

Maria Kulecka,

Urszula Kuklinska,

Jerzy Ostrowski,

Michał Mikula

Publication year - 2019

Publication title -

acta biochimica polonica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.452

H-Index - 78

eISSN - 1734-154X

pISSN - 0001-527X

DOI - 10.18388/abp.2019_2775

Subject(s) - penetrance , colorectal cancer , population , cancer , biology , genetics , medicine , oncology , environmental health , gene , phenotype

Effect of metal oxide nanoparticles on calli of two wheat varieties: Parabola (stress tolerant) and Raweta (sensitive) was studied. ZnO induced 10% larger membrane damage in Raweta calli. TiO2, Al2O3, and ZrO2 caused nearly 30% greater lactate dehydrogenase leakage for Raweta compared to Parabola. UV-irradiation of samples containing ZnO particles intensified this effect. Membrane lipid peroxidation in ZnO treated Raweta calli was twice as high as in Parabola and further increased after UV-irradiation. TiO2, Al2O3, and ZrO2 nanoparticles caused a 4-fold increase in malondialdehyde concentration in Raweta calli in comparison to Parabola calli. The nanoparticles studied damaged the cellular defense system by inactivating the antioxidative enzymes.

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