Prognostic value of broad-spectrum keratin clones AE1/AE3 and CAM5.2 in small cell lung cancer patients undergoing pulmonary resection
Author(s) -
A. Badzio
Publication year - 2019
Publication title -
acta biochimica polonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.452
H-Index - 78
eISSN - 1734-154X
pISSN - 0001-527X
DOI - 10.18388/abp.2018_2773
Subject(s) - keratin 8 , keratin , cytokeratin , tissue microarray , keratin 7 , pathology , lung cancer , immunohistochemistry , carcinoma , stage (stratigraphy) , proportional hazards model , survival analysis , medicine , biology , oncology , paleontology
Small cell lung carcinoma (SCLC) is an aggressive pulmonary neoplasm of neuroendocrine origin. Keratins form a large group of intermediate filaments, which are major structural proteins in epithelial cells and carcinomas. SCLC shows a wide spectrum of keratin expression, from very strong to completely negative. A prognostic role of keratin expression in SCLC is unknown.
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