Lactose intolerance, lactose malabsorption and genetic predisposition to adult-type hypolactasia in patients after restorative proctocolectomy | Zendy

Jarosław Walkowiak | Zendy; Ewa Fidler-Witoń | Zendy; Aleksandra Glapa-Nowak | Zendy; Jacek Paszkowski | Zendy; Maciej BorejszaWysocki | Zendy; Anna Miśkiewicz-Chotnicka | Zendy; Tomasz Banasiewicz | Zendy; Aleksandra Lisowska | Zendy

Open Access

Lactose intolerance, lactose malabsorption and genetic predisposition to adult-type hypolactasia in patients after restorative proctocolectomy

Author(s) -

Jarosław Walkowiak,

Ewa Fidler-Witoń,

Aleksandra Glapa-Nowak,

Jacek Paszkowski,

Maciej BorejszaWysocki,

Anna Miśkiewicz-Chotnicka,

Tomasz Banasiewicz,

Aleksandra Lisowska

Publication year - 2019

Publication title -

acta biochimica polonica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.452

H-Index - 78

eISSN - 1734-154X

pISSN - 0001-527X

DOI - 10.18388/abp.2018_2730

Subject(s) - malabsorption , lactose intolerance , lactase , gastroenterology , lactose , proctocolectomy , medicine , genetic predisposition , familial adenomatous polyposis , ulcerative colitis , chemistry , food science , cancer , colorectal cancer , disease

This study provides up-to-date findings on lactose malabsorption, lactose intolerance and genetic predisposition to adult-type hypolactasia in 72 patients after restorative proctocolectomy (RPC). The lactose malabsorption was assessed by hydrogen-methane breath test. Genetic predisposition to adult-type hypolactasia was assessed by detecting -13910T/C polymorphism in the lactase gene. Lactose intolerance was more frequent in UC (ulcerative colitis) patients than FAP (familial adenomatous polyposis) patients (77.5% vs. 55.2%; p=0.01). The C/C genotype of the lactase gene was observed in 39.1% subjects with no significant difference between UC and FAP patients. Lactose malabsorption occurred in 10.1% of subjects and almost only in patients with genetic predisposition, with the same frequency in UC and FAP patients.

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